NAD-Binding Domain

**Semantic type:** Amino Acid Sequence

**Definition:** The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion). (NCI)

**Synonyms:** - NAD-Binding Fold