Rifabutin

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04)

**Synonyms:** - LM-427 - Mycobutin - Mycobutin - RIFABUTIN - rifabutin