Activating ERBB3 Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ERBB3 gene that results in constitutive activation of receptor tyrosine-protein kinase erbB-3 and its downstream signaling pathways.

**Synonyms:** - Activating Erb-B2 Receptor Tyrosine Kinase 3 Gene Mutation - Activating ErbB-3 Gene Mutation - Activating HER-3 Gene Mutation - Activating HER3 Gene Mutation - Activating V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 3 Gene Mutation - Activating V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 Gene Mutation - Activating c-erbB-3 Gene Mutation - Activating c-erbB3 Gene Mutation