Trioxifene Mesylate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A mesylate salt form of trioxifene, a nonsteroidal selective estrogen receptor modulator (SERM). Trioxifene competitively inhibits the binding of estradiol to estrogen receptor alpha (ER alpha), resulting in ER alpha-mediated gene expression. Clinical development of Trioxifene has not proceeded because of lack of superior results over tamoxifen and side effect profile. (NCI)

**Synonyms:** - 3,4-Dihydro-2-(p-methoxyphenyl)-1-naphthyl p-(2-(1-pyrrolidinyl)ethoxy)phenyl Ketone Methanesulfonate - Compound 133314 - LY-133314 - TRIOXIFENE MESYLATE - Trioxifene Mesilate