Gallium Ga 68 Boclatixafortide

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of a synthetic, cyclic pentapeptide analog of stromal-cell derived factor-1 (SDF-1 or CXCL12), which is a ligand for chemokine receptor C-X-C chemokine receptor type 4 (CXCR4), that is radiolabeled, via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA), with the radioisotope gallium Ga 68 (Ga68; 68Ga), with potential use for imaging CXCR4-expressing cells upon positron emission tomography (PET)/computed tomography (CT). Upon administration of 68Ga pentixafor, the pentixafor moiety targets and binds to CXCR4-expressing cancer cells. Upon PET/CT, CXCR4-expressing cancer cells can be visualized and the expression status of the receptor can be assessed. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasis.

**Synonyms:** - 68GA-CPCR4-2 - 68Ga Pentixafor - CPCR4-2 GA-68 - GALLIUM (68GA) BOCLATIXAFORTIDE - Ga-68 Pentixafor - Ga68 Pentixafor - Gallium (68GA) Boclatixafortide - Gallium Ga 68 Pentixafor - Pentixafor Gallium GA-68 - [68Ga] Pentixafor