Clodronate Disodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

**Synonyms:** - Bonefos - Bonefos - CL2MDP - CLODRONATE DISODIUM - Clasteon - Clodronate - Clodronic Acid Disodium Salt - Dichloromethylene Diphosphonate - Difosfonal - Loron - Mebonat - Ossiten - clodronate