Activating AKT1 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the AKT1 gene that results in constitutive activation of RAC-alpha serine/threonine-protein kinase and its downstream signaling pathways.

**Synonyms:** - AKT1 Activating Mutation - Activating AKT Gene Mutation - Activating v-akt Murine Thymoma Viral Oncogene Homolog 1 Gene Mutation