NECTIN2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NECTIN2 wild-type allele is located in the vicinity of 19q13.32 and is approximately 43 kb in length. This allele, which encodes nectin-2 protein, is involved in viral entry, adherens junction organization and the modulation of receptor-mediated signaling in T-cells. Variation in the gene in subjects with multiple sclerosis may be associated with the severity of the disorder.

**Synonyms:** - CD112 - HVEB - Nectin 2 Gene - Nectin Cell Adhesion Molecule 2 wt Allele - PRR2 - PVRL2 - PVRR2 - Poliovirus Receptor-Like 2 Gene - Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) Gene - Poliovirus Receptor-Related 2 Gene