Afuresertib Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of afuresertib, an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B), with potential antineoplastic activity. Upon oral administration, afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

**Synonyms:** - AFURESERTIB HYDROCHLORIDE