CRDH, Rat Strain

**Semantic type:** Mammal

**Definition:** Non-insulin-dependent overt diabetes: blood glucose 384+/- 134 mg/dl (plasma insulin at 60 min following intragastric glucose load 83.3 +/-10.2mU/mL) and hypertension blood pressure 176 +/-8mmHg. There was severe diffuse diabetic glomerulosclerosis and severe hypertensive changes in arteries and arterioles characterised by fibrinoid necrosis and/or onion skin lesions as well as smooth muscle hyperplasia. Myocardial changes were prominent, with foci of ischemic necrosis and hyperplastic vascular changes.