Sodium Phenylbutyrate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

**Synonyms:** - 4-Phenylbutyric Acid, Sodium Salt - Buphenyl - Phenylbutyrate Sodium - SODIUM PHENYLBUTYRATE - SPB11 - Sodium 4-Phenylbutyrate - Sodium 4-phenylbutyrate - phenylbutyrate