FH, Rat Strain

**Semantic type:** Mammal

**Definition:** It has been suggested that FH rats represent a genetic model of depression They have altered serotonergic function (Aulka et al, 1994a), they exhibit differential responses to serotonin agonists and antagonists compared with other strains (Meehan and Schechter, 1994), and long-term treatment with imipramine, clomipramine and clorgyline produced significant decreases in plasma corticosterone levels, supporting this suggestion (Aulka et al, 1993).