Grade 3 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

**Semantic type:** Finding

**Definition:** Severe skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)

**Synonyms:** - Grade 3 Palmar-plantar erythrodysesthesia syndrome - Grade 3 Palmar-plantar erythrodysesthesia syndrome