Grade 4 Leukoencephalopathy, CTCAE

**Semantic type:** Finding

**Definition:** Life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly

**Synonyms:** - Grade 4 Leukoencephalopathy - Grade 4 Leukoencephalopathy