Sorivudine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market.

**Synonyms:** - (+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil - (E)-1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione - 1-Beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil - 2,4(1H,3H)-pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl) - 5-(2-bromovinyl)-1-beta-D- arabinofuranosyluracil - 5-Bromovinyl-araU - BV-araU - Bravavir - SORIVUDINE - SQ 32756 - Usevir - YN-72 - sorivudine