DBA/1 Mouse

**Semantic type:** Mammal

**Definition:** Derived from crosses made by Little in 1929-1930 between DBA progenitors. The DBA/1 mouse has a q H2 haplotype and carries the Cdh23^ahl mutation that results in progressive hearing loss after 10 months of age. The DBA/1 and DBA/2 mice differ at loci Car2, Ce2, Hc, H2, If1, Lsh, Tla, and Qa3. The strain is commonly used as a model for rheumatoid arthritis as it mimics hallmarks of the human disease when immunized with type II collagen.

**Synonyms:** - DBA/1 - DBA/1