Tirapazamine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)

**Synonyms:** - 3-Amino-1,2,4-benzotriazine-1,4-dioxide - SR 4233 - SR-4233 - SR4233 - TIRAPAZAMINE - Tirazone - WIN 59075 - WIN-59075 - WIN59075 - tirapazamine