Activating ALK Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ALK gene that results in constitutive activation of both ALK tyrosine kinase receptor protein and its downstream signaling pathways.

**Synonyms:** - Activating ALK Mutation - Activating ALK Receptor Tyrosine Kinase Gene Mutation - Activating Anaplastic Lymphoma Kinase Receptor Gene Mutation - Activating Anaplastic Lymphoma Receptor Tyrosine Kinase Gene Mutation - Activating CD246 Gene Mutation