Activating ROS1 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ROS1 gene that results in constitutive activation of both proto-oncogene tyrosine-protein kinase ROS and its downstream signaling pathways.

**Synonyms:** - Activating MCF3 Gene Mutation - Activating ROS Gene Mutation - Activating ROS Proto-Oncogene 1, Receptor Tyrosine Kinase Gene Mutation - Activating c-ros-1 Gene Mutation