Autologous TCR-engineered T-cells IMA201

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.

**Synonyms:** - ACTengine IMA201 - Autologous T-cell Receptor-engineered T-cells IMA201 - IMA 201 - IMA-201 - IMA201 - IMA201 Autologous T-lymphocytes - IMA201 T-cells