Elimusertib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor, with potential antineoplastic activity. Upon oral administration, elimusertib selectively binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling. This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and cell survival.

**Synonyms:** - ATR Inhibitor BAY1895344 - ATR Kinase Inhibitor BAY1895344 - BAY 1895344 - BAY-1895344 - BAY1895344 - ELIMUSERTIB