Giredestrant

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, giredestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.

**Synonyms:** - GDC 9545 - GDC-49545 - GIREDESTRANT - RG6171 - SERD GDC-9545 - Selective Estrogen Receptor Degrader GDC-9545 - Selective Estrogen Receptor Downregulator GDC-9545