Ziconotide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain.

**Synonyms:** - Prialt - Prialt - SNX 111 - SNX-111 - ZICONOTIDE - ziconotide