Denileukin Diftitox

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A cytotoxic recombinant fusion protein consisting of the human cytokine interleukin-2 (IL-2) fused to diphtheria toxin fragments A and B, containing both the catalytic and translocation domains, with potential antineoplastic activity. Upon administration, the IL-2 moiety of denileukin difitox targets and binds to IL-2 receptors. After internalization by IL-2 receptor-expressing cells via endocytosis, denileukin difitox is proteolytically cleaved. This releases the catalytic domain of the toxin moiety, which catalyzes the transfer of the ADP-ribose moiety of NAD to a diphthamide residue of elongation factor 2 (EF-2). This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in an inhibition of translation and cell death.

**Synonyms:** - DAB(389)-Interleukin-2 - DAB(389)IL-2 - DAB-IL2 - DAB389 Interleukin-2 - DAB389 Interleukin-2 Immunotoxin - DAB389IL-2 - DAB389IL2 - DABIL2 - DENILEUKIN DIFTITOX - Denileukin Diftitox-cxdl - Denileukin diftitox - Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777 - E7777 - Interleukin-2 Fusion Protein - Interleukin-2 Fusion Toxin - LY 335348 - LY-335348 - LY335348 - Lymphir - Ontak - Ontak - Remitoro - denileukin diftitox