Inactivating ERBB2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ERBB2 gene that either inhibits expression of the receptor tyrosine-protein kinase erbB-2 protein or results in the translation of an inactive receptor tyrosine-protein kinase erbB-2 protein.

**Synonyms:** - CD340 Inactivating Mutation - HER-2 Inactivating Mutation - HER2 Inactivating Mutation - HER2/Neu Inactivating Mutation - Inactivating HER2 Mutation - Loss of Function ERBB2 Mutation - Loss of Function HER2 Mutation