MUC1 SP Vaccine

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A therapeutic cancer vaccine comprised of a synthetic, 21-mer long peptide (LP) derived from the entire signal peptide (SP) domain of the tumor-associated antigen (TAA) mucin 1 (MUC1), with potential immunomodulating and antineoplastic activities. Upon intradermal administration, MUC1 SP vaccine may stimulate the host immune system to mount robust cytotoxic T-lymphocyte (CTL) and B-cell responses against MUC1-expressing tumor cells, resulting in tumor cell apoptosis and decreased tumor growth. MUC1 is overexpressed on many tumor cell types.

**Synonyms:** - IMMUCIN - ImMucin - MUC1-SP-L Vaccine - Mucin 1 Signal Peptide Vaccine - SP MUC1 Vaccine - VXL-100 - VXL100