PFKFB4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PFKFB4 wild-type allele is located in the vicinity of 3p21.31 and is approximately 45 kb in length. This allele, which encodes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 protein, is involved in the regulation of glycolysis. Expression of the gene by hypoxic cancer cells is essential to their survival.

**Synonyms:** - 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 wt Allele