DEPDC5 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human DEPDC5 wild-type allele is located within 22q12.2-q12.3 and is approximately 153 kb in length. This allele, which encodes GATOR complex protein DEPDC5, is involved in the modulation of signaling by Ras-related GTP-binding proteins. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci and with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection.

**Synonyms:** - DEP Domain Containing 5 wt Allele - DEP.5 - FFEVF - FFEVF1 - KIAA0645