Androgen Receptor Antagonist ONC1-0013B

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist ONC1-13B specifically binds to AR, prevents AR activation, downregulates AR expression and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.

**Synonyms:** - (R)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxo-7-oxa-1,3-diazaspiro[4.4]nonan-1-yl)-2-fluoro-N-methylbenzamide - AR Antagonist ONC1-0013B - ONC 10013B - ONC 113B - ONC-10013B - ONC1-0013B - ONC1-13B - ONC1-13B - ONC10013B