Androgen Receptor Antagonist BAY 1161116

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist BAY 1161116 specifically binds to AR, inhibits AR activation, and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.

**Synonyms:** - AR Antagonist BAY 1161116 - BAY 1161116 - BAY-1161116 - BAY1161116