TAFIa Inhibitor DS-1040b

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor (TAFIa; carboxypeptidase B2; CPB2), with potential fibrinolytic activity. Upon DS-1040 infusion, this agent binds to and inhibits TAFIa. This abrogates TAFIa-mediated inhibition of fibrinolysis. This induces fibrinolysis, degrades fibrin clots and prevents thrombus formation. TAFIa, a carboxypeptidase that is activated by thrombin, cleaves C-terminal amino acid residues from fibrin, which prevents binding and activation of plasminogen and inhibits plasmin-mediated fibrinolysis.

**Synonyms:** - (2S)-5-amino-2-[[1-(4-methylcyclohexyl)imidazol-4-yl]methyl]pentanoic Acid - CPB2 Inhibitor DS-1040b - Carboxypeptidase B2 Inhibitor DS-1040b - Carboxypeptidase U Inhibitor DS-1040b - DS 1040 - DS-1040 - DS-1040 - DS-1040b - DS1040 - Inhibitor of Activated Thrombin Activatable Fibrinolysis Inhibitor DS-1040b