Telotristat Ethyl

**Semantic type:** Pharmacologic Substance

**Definition:** The ethyl ester form of telotristat, a tryptophan hydroxylase (TPH) inhibitor, with potential anti-serotonergic activity. Upon administration, telotristat binds to and inhibits the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.

**Synonyms:** - LX 1032 - LX 1606 - LX-1032 - LX-1606 - LX1032 - LX1606 - TELOTRISTAT ETHYL