Imaging Agent QRH-882260 Heptapeptide

**Semantic type:** Indicator, Reagent, or Diagnostic Aid

**Definition:** An orally bioavailable fluorescent imaging agent composed of the near-infrared (NIR) fluorophore cyanine 5 (Cy5) linked to a seven-amino acid long peptide that specifically binds to the tumor-associated antigen (TAA) epithelial growth factor receptor (epidermal growth factor receptor; EGFR), that can potentially be used for the imaging of EGFR-expressing tumor cells. Upon oral administration of the fluorescent imaging agent QRH-882260 heptapeptide, the peptide moiety selectively binds to EGFR expressed on tumor cells in the gastrointestinal (GI) tract. Upon fluorescence imaging, EGFR-expressing tumor cells can be visualized. EGFR, a member of the epidermal growth factor receptor family, is overexpressed on the surfaces of various tumors cells.

**Synonyms:** - Fluorescence Peptide QRH-882260 - Fluorescently-labeled Peptide QRH-882260 - Gln-Arg-His-Lys-Pro-Arg-Glu-Gly-Gly-Gly-Ser-Lys(Cy5)-NH2 - QRH-882260 - QRH-882260 - QRH-882260 Cy-5-labeled Heptapeptide - QRHKPRE-GGGSK-(Cy5)-NH2