Fanregratinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon administration, fanregratinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases (RTKs) upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.

**Synonyms:** - FANREGRATINIB - FGFR Inhibitor HMPL-453 - FGFR1/2/3 Inhibitor HMPL-453 - HMPL 453 - HMPL-453 - HMPL453