Fluorine F 18 Integrin Alpha v Beta 6-targeted Peptide

**Semantic type:** Pharmacologic Substance

**Definition:** A radiotracer composed of an integrin alphaVbeta6 (aVb6) binding peptide (BP) radiolabeled with the radionuclide fluorine F 18, with potential integrin aVb6 imaging activity using positron emission tomography (PET). Upon administration, the fluorine F 18 integrin aVb6-targeted peptide selectively binds to integrin aVb6-positive cancer cells. During PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell types and has been associated with increased proliferation, migration and invasion of tumor cells.

**Synonyms:** - 18F-aVb6-BP - 18F-aVb6-Binding-Peptide - 18F-alphavbeta6-binding Peptide