HHV8-Positive Germinotropic Lymphoproliferative Disorder

**Semantic type:** Neoplastic Process

**Definition:** A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017)

**Synonyms:** - GLPD - HHV8+ GLPD - KSHV/HHV8-Positive Germinotropic Lymphoproliferative Disorder - KSVH/HHV8+ GLPD