Activating EML4/ALK Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the ALK portion of the EML4/ALK fusion gene that results in constitutive activation of the EML4/ALK fusion protein and its downstream signaling pathways. These mutations are associated with increased oncogenic potential.

**Synonyms:** - Activating EML4-ALK Fusion Gene Mutation - Activating EML4-ALK Gene Mutation - Activating EML4-ALK Mutation - Activating EML4/ALK Fusion Gene Mutation - Activating EML4/ALK Mutation