Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor.

**Synonyms:** - Most Closely HLA Matched Third-Party Donor Adenovirus Specific CTLs - Most Closely HLA Matched Third-Party Donor Adenovirus Specific T Cells