ATM Monoallelic Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** The presence of mutations in only one allele of the ATM gene that either lead to decreased of expression of the ATM protein or result in the translation of an inactive and potentially dominant-negative form of the ATM protein.

**Synonyms:** - A-T Mutated Monoallelic Gene Inactivation - AT Mutated Monoallelic Gene Inactivation - ATM Gene LOH - ATM Gene Loss of Heterozygosity - ATM LOH - ATM Loss of Heterozygosity - ATM Monoallelic Gene Inactivation - ATM Serine/Threonine Kinase Monoallelic Gene Inactivation - Ataxia Telangiectasia Mutated Monoallelic Gene Inactivation