Indican

**Semantic type:** Organic Chemical

**Definition:** A toxic metabolite derived from dietary proteins and tryptophan. In the intestine, proteins and tryptophan are converted to indole by tryptophanase-expressing organisms. In the liver, indole is hydroxylated to form indoxyl and indoxyl is sufated to produce indican. Overproduction of indican is associated with glomerular sclerosis, interstitial fibrosis and renal failure.

**Synonyms:** - 1H-Indol-3-yl Hydrogen Sulfate - 3-Indolyl Hydrogen Sulfate - 3-Indolyl Sulfate - 3-Indoxyl Sulfate - 3-Indoxylsulfuric Acid - INDICAN - Indol-3-yl Hydrogen Sulfate - Indol-3-yl Sulfate - Indoxyl Sulfate - Indoxylsulfuric Acid - Uindoxyl Sulfate