Modotuximab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon administration, modotuximab targets and binds to an epitope located in the extracellular domain (ECD) of EGFR, which causes internalization and degradation of EGFR, including the mutated EGFR variant III (EGFRvIII). This prevents EGFR-mediated signaling, thereby inhibiting EGFR-dependent tumor cell proliferation. EGFR, a receptor tyrosine kinase, is often overexpressed on the cell surfaces of various solid tumor cell types.

**Synonyms:** - 1024 DS - 1024-DS - Immunoglobulin G1, Anti-(human epidermal growth factor receptor extracellular domain III) (human-mus musculus monoclonal 1024 DS heavy chain), Disulfide with human-mus musculus monoclonal 1024 DS light chain, Dimer - MODOTUXIMAB - Zatuximab