PARN wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PARN wild-type allele is located in the vicinity of 16p13.12 and is approximately 197 kb in length. This allele, which encodes poly(A)-specific ribonuclease PARN protein, plays a role in the positive regulation of mRNA decay and telomere synthesis. Mutation of the gene is associated with telomere-related pulmonary fibrosis and/or bone marrow failure type 4 and autosomal recessive dyskeratosis congenita type 6.

**Synonyms:** - DAN - DKCB6 - Deadenylation Nuclease Gene - PFBMFT4 - Poly(A)-Specific Ribonuclease (Deadenylation Nuclease) Gene - Poly(A)-Specific Ribonuclease wt Allele