Ribaxamase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme|Pharmacologic Substance

**Definition:** An orally administered recombinant beta-lactamase that can be used to protect the gut microbiome from disruption caused by intravenous (IV) administered beta-lactam antibiotics. Upon administration, ribaxamase hydrolyzes the beta-lactam ring of susceptible antibiotics that were administered intravenously and are excreted into the intestines. This degrades the beta-lactam antibiotic, may prevent antibiotic-mediated damage in the gastrointestinal (GI) tract and may protect the gut microbiome. This may also prevent the overgrowth and associated infection with Clostridioides difficile and antibiotic-associated diarrhea. Ribaxamase is not systemically absorbed and does not interfere with the efficacy of IV beta-lactam antibiotics.

**Synonyms:** - RIBAXAMASE - SYN 004 - SYN-004 - SYN004