Volasertib Trihydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The trihydrochloride form of volasertib, a dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor, with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.

**Synonyms:** - VOLASERTIB TRIHYDROCHLORIDE