Vorapaxar Sulfate

**Semantic type:** Pharmacologic Substance

**Definition:** The sulfate salt form of vorapaxar, an orally bioavailable protease-activated receptor-1 (PAR-1) antagonist, with antiplatelet activity. Upon oral administration, vorapaxar binds to PAR-1 expressed on platelets, and inhibits PAR-1-mediated platelet aggregation. Vorapaxar inhibits thrombin-induced and thrombin receptor agonist peptide (TRAP)-induced platelet aggregation, and does not inhibit platelet aggregation induced by adenosine diphosphate (ADP), collagen or a thromboxane mimetic.

**Synonyms:** - SCH 530348 - VORAPAXAR SULFATE - Zontivity