Autologous CD8+ SLC45A2-specific T Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous CD8+ T lymphocytes targeting SLC45A2, a melanoma-associated antigen, with potential immunomodulating and antineoplastic activities. Following peripheral blood mononuclear cell (PBMC) collection and ex vivo expansion of SLC45A2-specific cytotoxic T-lymphocytes (CTLs), the autologous CD8+ SLC45A2-specific CTLs are re-infused into the patient, where they target and lyse SLC45A2-expressing tumor cells. While SLC45A2 is expressed by approximately 80% of cutaneous melanomas, its expression is limited in mature normal melanocytes, allowing high tumor selectivity and reduced potential for autoimmune toxicity.

**Synonyms:** - Autologous SLC45A2-specific CTLs - Autologous SLC45A2-specific Cytotoxic T Lymphocytes