Olinciguat

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with potential anti-inflammatory and vasodilating activities. Upon oral administration, olinciguat targets, allosterically binds to and enhances the nitric oxide (NO)-dependent catalytic activity of sGC. This enhances NO-sGC signaling and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This enhances NO/cGMP-mediated muscle relaxation, suppresses leukocyte-endothelial interactions and promotes vascular anti-inflammatory effects. The NO/sGC/cGMP signaling pathway plays an important role in vasodilation, blood flow and inflammatory processes. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to NO binding to heme.

**Synonyms:** - IW 1701 - IW-1701 - IW1701 - OLINCIGUAT - Soluble Guanylate Cyclase Stimulator IW-1701 - Stimulator of Soluble Guanylate Cyclase IW-1701 - sGC Stimulator IW-1701