Platinum Acetylacetonate-Titanium Dioxide Nanoparticles

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** A preparation of platinum acetylacetonate supported by sol-gel technology functionalized titania, with potential antineoplastic activity. Upon intravenous administration, the platinum moiety forms complexes with nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links, resulting in apoptosis and cell growth inhibition. Compared to platinum alone, the nanoparticle formulation allows increased delivery of platinum to the tumor site, thereby increasing efficacy while reducing systemic toxicity.

**Synonyms:** - NPt - NPt Nanomaterial - NPt Nanoparticles - NPt-Ca - Sol-gel NPt Nanomaterial - Sol-gel NPt Nanoparticles