Phosphorylated-FAK Y397

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A post-translationally modified form of focal adhesion kinase 1 (FAK; FAK1; PTK2) where the tyrosine (Y; Tyr) at residue 397 is phosphorylated. Cell adhesion-signaling promotes the association of FAK with Src family kinases, which stimulates autophosphorylation of FAK Y397 and creates a SH2-binding site on FAK to promote Src family kinase- and integrin-mediated signaling.

**Synonyms:** - FAK (Phospho Tyr397) - FAK (Phospho Y397) - FAK (pY397) - Focal Adhesion Kinase 1 Y397 Phosphorylated - Phospho-FAK (Y397) - Phospho-PTK2 (Tyr397) - Phospho-PTK2 (Y397) - Phosphorylated FAK Y397 - Phosphorylated-Focal Adhesion Kinase 1 Y397