Gallium Ga 68-NeoB

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate consisting of the gastrin-releasing peptide receptor (GRPR) antagonist, NeoBOMB1, linked via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during positron emission topography/computed tomography (PET/CT). Upon administration, gallium Ga 68-DOTA-NeoBOMB1 binds to GRPRs present on cancer cells. Upon binding, this radioconjugate can be used to quantify tumor uptake of NeoBOMB1 using PET/CT. GRPR, also known as bombesin receptor subtype 2, is a G-protein-coupled receptor that is overexpressed in some cancer types.

**Synonyms:** - 68Ga-NeoB - Gallium Ga 68 DOTA-NeoBOMB1 - Gallium Ga 68 NeoBOMB1 - [68Ga]-NeoB